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Dr. Varadi
holds an MS degree in Chemical Engineering and a Ph.D in
Organic Chemistry from the University of Pannonia, Veszprem,
Hungary (formerly Veszprem University of Chemical Engineering),
and a Ph.D. in Organometallic Chemistry from the National
Academy of Sciences, Budapest, Hungary. Dr. Varadi's Ph.D.
studies resulted in 20 publications and three patents; he
conducted postdoctoral studies in Neurobiochemistry under
the sponsorship of UNDP-EMBO-ICRO. Later, he became a faculty
member in the Department of Biochemistry at the Semmelweis
University Medical School in Budapest, Hungary.
In addition
he conducted successful research on the regulation of gene
expression and malignant transformation of endothelial cells.
Between 1982 and 1985, he was a visiting scientist at Yale
University in the Department of Molecular Biophysics and
Biochemistry. In 1989, he joined the faculty at the University
of Cincinnati College of Medicine where he held Associate
Professor positions in the Department of Pharmacology and
Biophysics, and in the Department of Cell Biology, Neurobiology
and Anatomy.
His research
activity has had a strong focus on excitation-contraction
coupling, and excitation-transcription coupling mechanisms
in the heart. Dr. Varadi's expertise is in gene expression,
protein-protein interactions and in calcium signaling. The
primary focus of his research has been the structure, function
and regulation of ion channels that participate in the generation
of cardiac action potential. He has cloned several ion channel
genes, and made important discoveries in heterologous gene
expression and membrane trafficking of ion channel proteins.
Dr. Varadi
also made landmark discoveries in deciphering the structure
of the ion conducting pathways of calcium channels, the
calcium channel antagonist binding site and the nature of
the voltage sensor. Dr. Varadi has developed an in depth
expertise regarding the mechanism of heart failure, in particular
in maladaptive transcription mechanisms governed by dysfunctional
calcium signaling. He has published 85 full research papers
in high-impact scientific journals.
In 2006, Dr.
Varadi joined RMD, Inc., where he now leads a research group
of six scientists engaged in the development of biological
and chemical sensors for detection of cells and biomolecules
present in very small amounts.
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